Brigitta stockinger biography for kids

  • Gitta obtained her PhD in Biology at the University of Mainz and then did postdoctoral studies in London and Cambridge, followed by a postdoc at the Cancer.
  • Marc Veldhoen.
  • Here we show that AHR is important for the termination of the regenerative response and the reacquisition of mature epithelial cell identity post injury.

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    Cell-intrinsic Aryl Hydrocarbon Organ signalling anticipation required pursue the dose of injury-induced colonic block out cells

    Authors

    Kathleen Shah #  1 , Muralidhara Rao Maradana #  1 , M Joaquina Delàs  1 , Amina Metidji  2 , Frederike Graelmann  3 , Miriam Llorian  1 , Probir Chakravarty  1 , Ying Li  1 , Mauro Tolaini  1 , Michael Shapiro  1 , Gavin Kelly  1 , Chris Cheshire  1 , Deendyal Bhurta  4 , Sandip B Bharate  4 , Brigitta Stockinger  5

    Affiliations

    • 1 The Francis Crick League, London, UK.
    • 2 Department pick up the check Oncology, Grieve Jude Children's Hospital, City, TN, USA.
    • 3 Immunology captain Environment, Bluff & Health check Sciences (LIMES) Institute, Academy of Metropolis, Bonn, Germany.
    • 4 Natural Byproducts & Sanative Chemistry Portion, CSIR - Indian Association of Centralizing Medicine, Canalise Road, Jammu, 180001, India.
    • 5 The Francis Crick Organization, London, UK. Brigitta.stockinger@crick.ac.uk.
  • brigitta stockinger biography for kids

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    Cell-intrinsic Aryl Hydrocarbon Receptor signalling is required for the resolution of injury-induced colonic stem cells

    Introduction

    The epithelium of the gastrointestinal tract has a remarkable ability for self-renewal, which results in replenishment of epithelial cells from intestinal stem cells (ISC) every 3–4 days. Recent studies have shown that even mature epithelial cells possess extensive plasticity which allows them to efficiently regenerate following intestinal injury1,2,3,4,5,6. Following DSS-induced damage in the colon, this process involves dedifferentiation and reprogramming of committed epithelial cells back into a fetal-like state, orchestrated by changes to the extracellular matrix (ECM) and activation of the mechano-sensing transcriptional activators Yap and Taz1. Dysregulation of the pathways involved in tissue repair and differentiation underlies inflammatory disorders of the gastrointestinal tract and the susceptibility to malignant transformation2,3.

    The increase in inflammatory disorders of the gastrointestinal tract over the last 50 years suggests that environmental factors have a major role in triggering or exacerbating such diseases7 but on the other hand environmental factors also shape physiological processes in the gut. Our focus as

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    From origins to open questions – Ten years of BMC Biology

    BMC Biology was launched as the flagship journal of BioMed Central in 2003, and we cannot leave a ten-year anniversary unmarked. But suspecting a reluctance to dwell on history, in this age when it is enough trouble to keep up with the breakneck present, we have in this collection of anniversary articles looked resolutely forward, and invited the authors of some of our most highly cited articles to produce updates on progress since they were published, and our Editorial Board members to contribute the open questions they would like to see answered in their fields. Even Patrick Brown, who spoke to us about the origins of open access, had his eyes so firmly fixed on the far horizon ten years ago that his vision remains in the future; and Peter Walter, with whom we did indulge in a little history in his interview on the origins of re-review opt-out, addresses an issue that remains perennial.